Professional sharing

Research on metabolites in drug discovery and development | Hongren Pharma Share

2025-01-11
Drug metabolism research runs through the entire process of drug development, and understanding the metabolic pathway and metabolite structure of compounds is important for the design and optimization

Drug metabolite identification: Bridging nonclinical to clinical drug development

2025-01-11
Drug metabolism research runs through the entire process of drug development, and understanding the metabolic pathway and metabolite structure of compounds is very important for the design and optimiz

Application of LC-MS technique in quantitative analysis of biological samples of oligonucleotides

2025-01-11
Oligonucleotides are one of the most promising drug fields in biomedical research and development. These drugs are oligonucleotides composed of 12 to 30 nucleotides synthesized chemically. At...

Macro Pharma flow cytometry technology share

2025-01-11
Flow Cytometry (FCM) is a technique that uses flow cytometry to qualitatively and quantitatively analyze and sort a variety of fluorescently labeled single cells or other biological particles at a fun

The application of chemical derivatization technology in biological analysis |

2024-11-22
In general, compounds suitable for LC-MS analysis need to have the following characteristics: good chemical stability, easy ionization (ESI, APCI), high abundance, good selectivity of product ions,...

Common problems and solutions for bioanalysis of polypeptide drugs based on LC-MS detection platform

2024-12-08
The biological analysis of polypeptide mainly includes PK pharmacokinetic test, TK pharmacokinetic test and ADA test. The methods used in the analysis mainly include LC-MS/MS and LBA ligand receptor

Key considerations and cases of mesenchymal stem Cell bioanalysis Share | Hongren Pharma Report of the 2nd Greater Bay Area Cell Gene Therapy Development Forum

2024-11-25
Biological analysis of stem cells mainly includes: 1, PK and distribution. Among them, clinical distribution detection is difficult due to the limitation of sample sampling. 2. Immunogenicity assessme

Evaluation indexes of blood-brain barrier in Kp,uu-CNS drugs

2024-11-22
Only the concentration of free CNS drugs at the therapeutic target can play a pharmacological role, and the concentration of free CNS drugs in the brain has a good correlation with clinical effects...