Research on Novel Delivery System drug DMPK in New Drug Research and development and its cases Share | Hongren Report of the 14th Academic Conference on Drug and Chemical Foreign Body Metabolism of Chinese Pharmacological Society
2025-01-11Non-clinical and clinical DMPK studies of the new delivery system provide data support for elaborating the characteristics of ADME in vivo. Robust bioanalytical methods are critical. New delivery syst
The application of chemical derivatization technology in biological analysis |
2024-11-22In general, compounds suitable for LC-MS analysis need to have the following characteristics: good chemical stability, easy ionization (ESI, APCI), high abundance, good selectivity of product ions,...
[Big coffee gathers in Wuhan East Lake, bright spots] 132+615 pharmaceutical colleagues talk about the frontier of medicine and seek the future of the industry!
2023-07-24The First Wuhan East Lake Biomedical Innovation and Development Forum, co-sponsored by Hongren Pharmaceutical and Tongji Medical College of Huazhong University of Science and Technology, was successfu
【 Macropharma 】 Structural characterization of ADC drugs and case sharing
2023-10-07Antibody-drug conjugates (ADCs) consist of three main components: Antibodies that selectively recognize antigens on the surface of cancer cells, drug payloads that kill cancer cells, and linkers th...
Common problems and solutions for bioanalysis of polypeptide drugs based on LC-MS detection platform
2024-12-08The biological analysis of polypeptide mainly includes PK pharmacokinetic test, TK pharmacokinetic test and ADA test. The methods used in the analysis mainly include LC-MS/MS and LBA ligand receptor
Key considerations and cases of mesenchymal stem Cell bioanalysis Share | Hongren Pharma Report of the 2nd Greater Bay Area Cell Gene Therapy Development Forum
2024-11-25Biological analysis of stem cells mainly includes: 1, PK and distribution. Among them, clinical distribution detection is difficult due to the limitation of sample sampling. 2. Immunogenicity assessme
Evaluation indexes of blood-brain barrier in Kp,uu-CNS drugs
2024-11-22Only the concentration of free CNS drugs at the therapeutic target can play a pharmacological role, and the concentration of free CNS drugs in the brain has a good correlation with clinical effects...
Analysis on the application of SEC-MALS detection of molecular weight and molecular weight distribution
2024-09-27SEC-MALS instrument Introduction and detection of molecular weight and molecular weight distribution principle SEC-MALS full name 18 Angle laser light scattering gel chromatography system, is the use
DMPK characteristics of polypeptide drugs and key factors for bioanalysis and detection | Shanghai Zhangjiang Life Science Salon Hongren Pharmaceutical Report sharing
2024-08-02In the keynote speech, Dr. Huang Jiangeng, combined with the rich project experience accumulated by Macro Medicine, discussed the characteristics of peptide drugs DMPK and the main difficulties and st
Small nucleic acid drug non-clinical DMPK research concerns and examples | Suzhou T20 Macro and tough theme report sharing
2024-07-19From July 11 to 13, 2024, "The Road to the Future of Chinese Pharmaceutical Innovation - The 20th Anniversary Conference of TongXieyi (T20)" was successfully concluded in Suzhou!The theme of this "...
Macroren's non-clinical DMPK research services helped Agomelatine transdermal patch gain clinical approval
2024-05-17On May 14, according to the official media of Xinwen Biology, its clinical application for Agomelatine transdermal patch was successfully approved. This is the world's first Agomelatine transdermal...